Our understanding of the interactions between cells and extracellular matrix (ECM) has been very limited due to a lack of tools able to probe this interface either in vivo, where imaging is challenging, or in vitro with standard culture systems (e.g., tissue culture plates). The study of the spatio-temporal deposition and composition of the ECM is important to understand cell behavior. To address this, we are employing metabolic labelling techniques using the cell endogenous synthesis and translation machinery. This project aims to track ECM composition/deposition over time as a function of the infection process.
