Our ability to study interactions between cells and the extracellular matrix (ECM) has been limited by the lack of tools capable of probing this interface—both in vivo, where imaging poses challenges, and in vitro, where standard culture systems (e.g., tissue culture plates) do not fully replicate native environments. Understanding the spatio-temporal deposition and composition of the ECM is crucial for deciphering cell behavior.

To address this, we employ metabolic labeling techniques that leverage the cell’s endogenous synthesis and translation machinery. This project aims to track ECM composition and deposition over time in the context of infection. A particular focus is on ECM alterations during lung infections caused by mycobacteria and in pre-existing pathological conditions such as tissue fibrosis. By integrating tissue engineering, biomaterials, and infection dynamics, we seek to identify novel therapeutic targets.

The team working on the project

The sponsors of the project